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Zebra ZD621 Healthcare
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Zebra ZD621 Healthcare

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ZD621 Healthcare

Invest in the best: premium features, maximum performance and unmatched security for years of quality printing

The Zebra ZD621 Healthcare gives clinical, lab and pharmacy teams a compact premium printer built for consistent desktop labeling in demanding healthcare workflows. It brings the ZD600 Series architecture, strong print performance and Zebra DNA software tools into a healthcare configuration designed for cleaner handling and easier day-to-day use.

This model is made for patient identification, specimen collection, prescription labeling, lab management and asset labeling. Standard Ethernet, USB 2.0 and USB host connectivity help it fit into existing workstations, while optional wireless and media-handling choices let the printer grow with changing requirements.

Your Future Printing Starts Here

Technology for Today, Innovation for Tomorrow

ZD600 Series printers are designed around an architecture that can support expanding printer features and software over time. The ZD621 Healthcare can be configured with current wireless options, including Wi-Fi 6/6E support with Bluetooth® 5.3, to align with modern healthcare network upgrades.

Expect the Best

Premium Printing Performance

Premium desktop printing helps teams keep pace at registration desks, nursing stations, labs and pharmacies. The ZD621 Healthcare supports direct thermal and thermal transfer workflows, optional 300 dpi resolution and flexible media support for common healthcare labels and wristbands.

Simple to Setup, Easy to Maintain

Operate with Ease, Securely

Zebra DNA tools help simplify deployment, setup and remote management. Status icons, setup utilities and the standard healthcare touch LCD make printer status and configuration easier to handle with minimal training.

Premium Features, Small Footprint

Load Media Easily

OpenACCESS™ media loading and color-coded touch points help staff replace media quickly. Thermal transfer configurations also support intuitive ribbon replacement to reduce interruptions during busy clinical shifts.

Engineered for Outstanding Print Quality

The ZD621 offers 203 dpi standard resolution, with 300 dpi available when smaller text, dense barcodes or compact labels need added detail. Thermal transfer models include Zebra print-quality features designed to keep labels and tags consistent across print speeds.

See Printer Status in Color and Change Settings with a Touch

The 4.3-inch full-color touch LCD is standard on healthcare models, giving users clear access to printer status, setup menus and guided printer functions. This helps reduce training time and makes common adjustments easier at the point of use.

Hassle-Free Integration

Backwards Compatible with Virtually Any Existing Thermal Printer

Support for ZPL and EPL makes it easier to place the ZD621 Healthcare into existing label environments. Zebra DNA Printer Emulations can also help organizations preserve legacy label formats and applications during printer fleet transitions.

Comprehensive Communication to Connect Your Way

Ethernet, USB 2.0, USB host and serial connectivity are standard on the ZD621. Optional dual wireless radio configurations support Wi-Fi and Bluetooth connections, and NFC Print Touch helps simplify pairing and access to support resources.

Innovative Features that Work for You

Add Mobility for On-the-spot Printing

An optional battery can power the printer through mobile workflows, helping teams print labels closer to the work instead of returning to a fixed workstation. This can reduce extra steps and support more accurate labeling at the point of care.

Moveable Sensor Means More Flexibility

A full-width moveable reflective/black mark sensor and a multi-position transmissive/gap sensor help the printer handle a wide range of roll-fed and fan-fold media, including labels, tag stock, receipt paper and supported wristbands.

Zebra DNA for Printers

Confident and Secure Printing, Without the Hassle

Zebra DNA, powered by Link-OS™, supports setup, secure operation, management and optimization across the printer lifecycle. These tools help keep healthcare printing dependable as workflows and security expectations evolve.

Update, Troubleshoot and Monitor, All from a Single Location

Printer Profile Manager Enterprise gives administrators a way to manage, secure and troubleshoot networked Zebra DNA printers remotely, helping reduce hands-on printer maintenance across larger facilities.

Unmatched Printing Security

PrintSecure, part of Zebra DNA, helps administrators strengthen printer security by supporting secure configuration, identifying vulnerabilities and limiting unauthorized access across connected printer environments.

Supplies, Service and Support

Zebra Certified Supplies

Zebra Certified Supplies are designed and tested to deliver consistent, optimized performance in Zebra printers. For healthcare workflows, the right labels, wristbands and receipt media help preserve readability and reduce disruptions tied to poor supplies performance.

Backed by Zebra's Worldwide Service and Support

Zebra service and support options help organizations keep printers in service across distributed clinical environments. Zebra OneCare™ maintenance plans provide enhanced support options that go beyond standard warranty coverage.

Healthcare Applications

The ZD621 Healthcare supports common healthcare workflows including specimen collection, prescription labeling, lab management, patient ID wristbands, asset labels and patient records.

Key Specifications

The ZD621 supports thermal transfer or direct thermal printing, 203 dpi standard resolution, optional 300 dpi resolution, 512 MB Flash memory and 256 MB SDRAM. The maximum print width is 4.09 inches at 203 dpi and 4.27 inches at 300 dpi, with print speeds up to 8 inches per second at 203 dpi and 6 inches per second at 300 dpi.

Dimension
  • Direct Thermal: 8.7" L x 7.0" W x 5.9" H
  • Thermal Transfer: 10.5" L x 8.0" W x 7.5" H
Weight
  • Direct Thermal: 3.6 lbs.
  • Thermal Transfer: 5.5 lbs.
Print Method
  • Direct Thermal
  • Thermal Transfer
Resolution
  • 203 dpi
  • 300 dpi optional
Print Width
  • 203 dpi: up to 4.09"
  • 300 dpi: up to 4.27"
Print Speed
  • 203 dpi: up to 8" per second
  • 300 dpi: up to 6" per second
Media Width
  • Direct Thermal: 0.585" to 4.25"
  • Thermal Transfer: 0.585" to 4.65"
Label Length
  • Minimum: 0.25"
  • Maximum: 39.0"
Media Roll Size
  • Maximum OD: 5.0"
  • Core ID: 0.5" and 1.0" standard
  • Optional adapters: 1.5", 2.0", and 3.0"
Media Thickness
0.003 in. (0.08 mm) min.; 0.0075 in. (0.19 mm) max. (tear-off mode only)
Media Types
Roll-fed or fan-fold, die cut or continuous with or without black mark, label or tag stock, continuous receipt paper, wristbands
Ribbon Outside Diameter
2.6 in./66 mm (300 m); 1.34 in./34 mm (74 m)
Ribbon Standard Length
984 ft. (300 m); 243 ft. (74 m)
Ribbon Ratio
  • 1:4 ribbon to media (300 m)
  • 1:1 ribbon to media (74 m)
Ribbon Width
1.33 in./33.8 mm — 4.3 in./109.2 mm
Ribbon Width
  • 300 meter ribbon 1 in./25.4 mm
  • 74 meter ribbon 0.5 in./12.7 mm
Operating Temp.
40° to 105° F/4.4° to 41° C
Operating Humidity
10% to 90% non-condensing
Storage Humidity
5% to 95% non-condensing
Electrical
Auto-detectable (PFC Compliant) 100-240VAC, 50-60Hz; ENERGY STAR certified; Energy Efficiency Level VI certified; optional 2750 mAh battery; Healthcare models include IEC60601-1 certified power supply
Media Handling
Dispenser/Peeler: label peel and present with label present sensor (factory installed or field installable) Cutter (factory installed or field installable)
Communications
802.11ac Wi-Fi and Bluetooth 4.1 (dual radio), (factory installed or field installable)
Battery
Provides power to the printer to support a full shift of printing at maximum print speed; supports all connectivity and media handling options
Carrying Case
Carrying case with shoulder strap and handles makes it easy to bring your desktop printer and battery to the point of application
Keyboard Display Unit
Zebra Keyboard Display Unit (ZKDU) for stand- alone printing solutions
Media Locking Cabinet
Mechanical lock with 2 keys; Kensington™ lock slot; available on ZD621 healthcare direct thermal model only
Enclosed Power Supply
Attached power supply accessory for cord-free installation
Bar Code Ratios
2:1 and 3:1
1D Bar Codes
Code 11, Code 39, Code 93, Code 128, ISBT-128, UPC-A, UPC-E, EAN-8, EAN-13, UPC and EAN 2-or 5-digit extensions, Plessey, Postnet, Standard 2-of- 5, Industrial 2-of-5, Interleaved 2-of-5, Logmars, MSI, Codabar and Planet Code
2D Bar Codes
Codablock, PDF417, Code 49, DataMatrix, MaxiCode, QR Code, MicroPDF, Aztec
Fonts and Graphics
16 resident expandable ZPL II bitmap fonts, two resident scalable ZPL fonts, five resident expandable EPL2 fonts, native open-type font support, Unicode compliant. China units include SimSun simplified Chinese font
Printers Supplies
For industry-leading quality, service and thermal printing expertise, choose Zebra Certified Supplies to ensure consistent, optimized performance for your Zebra printer.
Environment
• RoHS Directive 2011/65/EU; Amendment 2015/863
A complete list of product and materials compliance, please visit www.zebra.com/environment
Included In The Box
Printer, empty ribbon take-up cores (1 in. and 0.5 in.)*, 300 m ribbon core adapters for non-Zebra ribbon (2)*, AC power supply, power cord(s), USB cable, Quick Start Guide, Regulatory Guide
* Empty ribbon take-up cores and ribbon core adapters included with ZD621 thermal transfer models only
Product Warranty
ZD600 Series printers are warranted against defects in workmanship and materials for a minimum period of 2 (two) years from the date of shipment. Warranty varies by region. For complete warranty details, please visit www.zebra.com/warranty
Print Spooler Reset (Used To Clear Stuck Print Queues)
Download
Windows Driver (Version 10)
Download
Zebra Setup Utility
Download
Zebra ZD621 Healthcare Accessory Guide
Download
Zebra ZD621 Healthcare Spec Sheet
Download

Shop ZD621 Healthcare Models

ZD6AL42-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$977.95

ZD6AH42-D01R01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.2, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ax, BT5.2

$1067.18

ZD6AH42-301F00EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial

$977.95

ZD6AH42-301L01EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ac, BT4, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac, BT4

$1155.56

ZD6AH42-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL.

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$889.60

ZD6AH43-301F00EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial

$1066.33

ZD6AH43-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$977.95

ZD6AL42-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$977.95

ZD6AL42-D21F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, Cutter, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Cutter

Print Method:

Direct Thermal

Interface:

USB, USB Host, Ethernet, Serial

$1177.87

ZD6AH43-D01R01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3

$1154.14

ZD6AL43-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$1066.33

ZD6AH42-301F00EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial

$977.95

ZD6AH42-301L01EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ac, BT4, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac, BT4

$1155.56

ZD6AH42-D01L01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ac, BT4, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac

$1067.18

ZD6AH43-301L01EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ac, BT4, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

300

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac, BT4

$1243.93

ZD6AH43-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$977.95

ZD6AH43-D01L01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ac, BT4, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac, BT4

$1155.56

Shop ZD621 Healthcare Accessories

P1080383-022

Media Core Adaptors for 1.5", 2.0", 3.0" diameter cores. Set of 1 each. Compatible with Zebra ZD421 & ZD621 Printers.

$60.32

P1079903-026

Replacement Power Supply for Zebra Desktop Printer. 75W/24V with US & EU AC cords. Compatible with: ZD410, ZD411, ZD420, ZD421, ZD620, ZD621, ZD500.

$200.83

P1080383-603

Battery for Zebra Desktop Printers. Compatible with ZD411, ZD421, ZD621, ZD410, ZD420, and ZD620. Requires Base Housing (P1080383-602 for ZD411/ZD611 / P1080383-600 for ZD421 & ZD621).

$767.50

P1080383-600

Base Housing for Zebra Printer Battery. Compatible with Zebra ZD421, ZD621, ZD420, and ZD620. Purchase Battery (P1080383-603) Separately.

$100.56

T47331IO-EA

Single Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core. Single Roll. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).

$10.00

P1112640-241

Kit, Printhead 300 dpi, ZD621T, ZD621R

$373.80

P1112640-240

Kit, Printhead 203 dpi, ZD621T, ZD621R

$179.09

P1112640-232

Kit, Upgrade, Cutter, ZD621T, ZD621R

$268.11

ZKDU-001-00

Keyboard Display Unit (ZKDU), For all EPL and ZPL Printers, 62-Key QW

$414.25

T47331IO-EA-6-ADDON

Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core, 6 Rolls. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).

$60.00

P1080383-234

Attached Power Supply for use with Printer Power Carts. This removes the need for an external Power Supply. Attached Power Supply sits below the printer and is compatible with the Zebra ZD421 and ZD621. Must Purchase AC Power Cable (29928 or 29926) Separately.

$328.44

29928

Universal AC Power Cord. 8ft (2.4m). 125.0 V / 13 A.

$17.51

29926

Universal AC Power Cord. 4ft (1.6m). 125.0 V / 13 A.

$15.12

P1112640-233

Peeler (Dispenser) Upgrade Module for Zebra ZD621T, ZD621R, and ZD421C Printers. NOT backwards compatible with the ZD420 or ZD620

$53.62

P1112640-239A

Kit, Wireless Module, WiFi 802.11ac, MFI 3.0, Bluetooth 4.1, USA & Canada, ZD621T, ZD421C

$234.61

SG-DM-CASE2-01

KIT, Accessory, Thermal Transfer Soft Carrying Case, ZD42X/ZD62X printer with battery attachment

$426.47

P1112640-238

Kit, Ethernet and Serial Module, ZD621T, ZD621R

$131.04

P1080383-037

ZD420C, Kit, Adapter bracket enables mounting a ZD420C in the same location as an existing GK/GX TT is currently mounted. Allows usage of the GK/GX TT hole pattern to mount a ZD420C

$60.32

BRKT-DPA-SK1-01

PrintKiosk mounting bracket for ZD4/6 printers and CC6000 tablet (75/100mm VESA mounting plate)

$365.36

BRKT-DPA-SK1-02

PrintKiosk mounting bracket for ZD4/6 printers and CC600 tablet (75mm only VESA mounting plate)

$365.36

P1112640-251

Kit, Platen Roller 203 dpi, ZD621T, ZD621R

$28.68

P1112640-252

Kit, Platen Roller 300 dpi, ZD621T, ZD621R

$28.68

105950-014

GX430T, KIT, Power Cord, U.S. 120V IEC320C13 (set of 5)

$59.87
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